Cerebral toxoplasmosis in an adolescent post allogeneic hematopoietic stem cell transplantation: successful outcome by antiprotozoal chemotherapy and CD4+ T‐lymphocyte recovery. Issue 1 (12th January 2015)

• Record Type: Journal Article
• Authors: Kerl, K.; Ehlert, K.; Brentrup, A.; Schiborr, M.; Keyvani, K.; Becker, K.; Rossig, C.; Groll, A.H.
• Is Part Of: Transplant infectious disease. Volume 17:Issue 1(2015)
• Page Start: 119
• Page End: 124
• Publication Date: 2015-01-12
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12344
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12344-abs-0001"> <title>Abstract</title> <p>Toxoplasmosis is a rare opportunistic infection in pediatric allogeneic hematopoietic stem cell transplant (allo‐HSCT) recipients and associated with severe T‐cell deficiency. Here, we report the successful management of cerebral toxoplasmosis in a 15‐year‐old adolescent 4 months post allo‐HSCT for non‐Hodgkin lymphoma through rapid invasive diagnostics, long‐term antiprotozoal chemotherapy, and an hematopoietic stem cell boost for persistently poor graft function. While supportive care and antiprotozoal chemotherapy achieved stabilization, definite improvement only occurred following recovery of CD4⁺ T lymphocytes to &gt;100 cells/μL. At 5 years after the diagnosis of toxoplasmosis, the patient is in continuing remission with normalized clinical and imaging findings.</p> </abstract>