Why is insulin pump treatment rarely used in adolescents and young adults with cystic fibrosis‐related diabetes?. Issue 1 (2nd July 2014)

• Record Type: Journal Article
• Authors: Scheuing, Nicole; Badenhoop, Klaus; Borkenstein, Martin; Konrad, Katja; Lilienthal, Eggert; Laubner, Katharina; Naeke, Andrea; Rami‐Merhar, Birgit; Thon, Angelika; Wiemann, Dagobert; Holl, Reinhard W; for the German/Austrian Diabetes Prospective Documentation Initiative
• Is Part Of: Pediatric diabetes. Volume 16:Issue 1(2015:Feb.)
• Page Start: 10
• Page End: 15
• Publication Date: 2014-07-02
• Subjects: Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12158
• Languages: English
• ISSNs: 1399-543X

Abstract

<abstract abstract-type="main" id="pedi12158-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pedi12158-sec-0001" sec-type="section"> <title>Background</title> <p id="pedi12158-para-0001">In type 1 diabetes (T1D), the use of continuous subcutaneous insulin infusion (CSII) has increased steadily in the last years. Compared with conventional insulin injection regimes, major advantages might be a nearly physiological insulin secretion, lower rates of hypoglycemia, higher flexibility in daily life, and increased quality of life. Data on CSII in cystic fibrosis‐related diabetes (CFRD) are scarce.</p> </sec> <sec id="pedi12158-sec-0002" sec-type="section"> <title>Objective</title> <p id="pedi12158-para-0002">To analyze current use of insulin pumps in CFRD and compare demographics of pump‐treated patients between CFRD and T1D.</p> </sec> <sec id="pedi12158-sec-0003" sec-type="section"> <title>Methods</title> <p id="pedi12158-para-0003">Data from the prospective German/Austrian diabetes patient registry on insulin‐treated patients with either CFRD (n = 515) or T1D (n = 43 165) aged >10 yr at manifestation of diabetes were analyzed.</p> </sec> <sec id="pedi12158-sec-0004" sec-type="section"> <title>Results</title> <p id="pedi12158-para-0004">A total of 4.1% (n = 21) of CFRD and 17.7% (n = 7647) of T1D patients received insulin pump treatment within the recent year of care (p < 0.001). Pump‐treated patients with CFRD had a significantly shorter duration of diabetes [median (Q<sub>1</sub>; Q<sub>3</sub>): 5.8 (2.9; 9.5) vs. 7.8 (4.3; 20.4) yr, p = 0.026] and tended to be younger [22.0 (18.2; 30.1) vs. 24.9 (17.3; 45.9) yr] than pump‐treated T1D patients. Age at initiation of CSII seemed to be lower in CFRD [19.2 (16.5; 29.2) vs. 23.3 (14.8; 43.5) yr]. Insulin pump therapy was used slightly more often in male CFRD patients than females (4.7 vs. 3.6%), whereas in T1D the opposite was observed (14.9 vs. 21.2%, p < 0.001). Discontinuation rate of CSII was higher in CFRD than T1D (30.0 vs. 12.7%, p = 0.005).</p> </sec> <sec id="pedi12158-sec-0005" sec-type="section"> <title>Conclusions</title> <p id="pedi12158-para-0005">Despite potential advantages, insulin pump therapy was rarely used among adolescent and young adult CFRD patients.</p> </sec> </abstract>