Ara h 2 and Ara h 6 sensitization predicts peanut allergy in Mediterranean pediatric patients. Issue 7 (10th December 2014)

• Record Type: Journal Article
• Authors: Agabriel, Chantal; Ghazouani, Ouafeh; Birnbaum, Joëlle; Liabeuf, Valérie; Porri, Françoise; Gouitaa, Marion; Cleach, Isabelle; Grob, Jean‐Jacques; Bongrand, Pierre; Sarles, Jacques; Vitte, Joana
• Is Part Of: Pediatric allergy and immunology. Volume 25:Issue 7(2014)
• Page Start: 662
• Page End: 667
• Publication Date: 2014-12-10
• Subjects: Allergy in children -- Periodicals; Immunologic diseases in children -- Periodicals; 617
• DOI: 10.1111/pai.12299
• Languages: English
• ISSNs: 0905-6157

Abstract

<abstract abstract-type="main" id="pai12299-abs-0001"> <title>Abstract</title> <sec id="pai12299-sec-0001" sec-type="section"> <title>Background</title> <p>Peanut allergy (PA) management was improved by the introduction of molecular allergology, but guidelines for Mediterranean patients are lacking. We aimed at evaluating peanut component‐resolved diagnosis as a diagnostic and prognostic tool in children from Southern France.</p> </sec> <sec id="pai12299-sec-0002" sec-type="section"> <title>Methods</title> <p>In 181 pediatric patients, PA diagnosis was founded on medical history, skin prick testing, serum‐specific IgE to <italic>Arachis hypogea</italic> extract and components, Pru p 4, and plant carbohydrates, and oral food challenge. Allergen microarray was also performed in 68 of these patients.</p> </sec> <sec id="pai12299-sec-0003" sec-type="section"> <title>Results</title> <p>In peanut‐allergic children (n = 117), IgE to Ara h 6 were most prevalent (64%), followed by Ara h 2 (63%), Ara h 1 (60%), and Ara h 9 (52%). Ara h 6 was the best predictor of PA. The second best predictor was the ratio of Ara h 2 IgE to peanut IgE (cutoff 0.113). Persistent childhood PA was associated with complex molecular profiles. Comparison of singleplex and microarray results showed poor concordance for Ara h 2 and Ara h 9.</p> </sec> <sec id="pai12299-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Ara h 6 and Ara h 2 are the best predictors of PA at diagnosis in Mediterranean pediatric patients. Ara h 1, Ara h 8, and molecular complexity are associated with PA persistence.</p> </sec> </abstract>