Low‐density lipoprotein and other predictors of response with telaprevir‐based therapy in treatment‐experienced HCV genotype 1 patients: REALIZE study. (11th November 2014)

• Record Type: Journal Article
• Authors: Berg, Thomas; Andreone, Pietro; Pol, Stanislas; Roberts, Stuart; Younossi, Zobair; Diago, Moises; Lawitz, Eric J.; Focaccia, Roberto; Foster, Graham R.; Horban, Andrzej; Lonjon‐Domanec, Isabelle; DeMasi, Ralph; Picchio, Gaston; Luo, Donghan; De Meyer, Sandra; Zeuzem, Stefan
• Is Part Of: Liver international. Volume 35:Number 2(2015:Feb.)
• Page Start: 448
• Page End: 454
• Publication Date: 2014-11-11
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.12703
• Languages: English
• ISSNs: 1478-3223

Abstract

<abstract abstract-type="main" id="liv12703-abs-0001"> <title>Abstract</title> <sec id="liv12703-sec-0001" sec-type="section"> <title>Background & Aims</title> <p>Predictors of response to treatment with peginterferon plus ribavirin are well established. In these post‐hoc analyses of the REALIZE study, we sought to identify predictors of response for telaprevir‐based triple therapy.</p> </sec> <sec id="liv12703-sec-0002" sec-type="section"> <title>Methods</title> <p>Patients from the REALIZE study with baseline data for all predictors evaluated (including baseline disease characteristics and demographics, prior treatment response and baseline laboratory assessments) were included in the post‐hoc analyses (<italic>n</italic> = 465). Univariate and multivariate analyses were used to evaluate factors predicting treatment outcomes.</p> </sec> <sec id="liv12703-sec-0003" sec-type="section"> <title>Results</title> <p>Sustained viral response (SVR) rates were 86% in prior relapsers, 63% in prior partial responders and 32% in prior null‐responders. In the final multivariate analysis, baseline factors predicting SVR were prior response to treatment [Odds ratio (OR) = 2.80; 95% confidence interval (CI), 2.13–3.69], low‐density lipoprotein (LDL) (≥2.6 mmol/L) (OR = 2.11; 95% CI, 1.52–2.93), HCV genotype (OR = 0.58; 95% CI, 0.36–0.93), and maximum alanine amino transferase and aspartate amino transferase (OR = 0.62; 95% CI, 0.40–0.97).</p> </sec> <sec id="liv12703-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Prior response to peginterferon plus ribavirin treatment and LDL levels are the main independent predictive markers of response with telaprevir‐based triple therapy.</p> </sec> </abstract>