Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats. (24th December 2014)

• Record Type: Journal Article
• Authors: Parkinson, S.; Tolbert, K.; Messenger, K.; Odunayo, A.; Brand, M.; Davidson, G.; Peters, E.; Reed, A.; Papich, M.G.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 1(2015:Jan./Feb.)
• Page Start: 104
• Page End: 112
• Publication Date: 2014-12-24
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12493
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12493-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12493-sec-0001" sec-type="section"> <title>Background</title> <p>Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration. However, clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats.</p> </sec> <sec id="jvim12493-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>To compare the effect of PO administered famotidine, fractionated omeprazole tablet (fOT), and omeprazole reformulated paste (ORP) on intragastric pH in cats. We hypothesized that both omeprazole formulations would be superior to famotidine and placebo.</p> </sec> <sec id="jvim12493-sec-0003" sec-type="section"> <title>Animals</title> <p>Six healthy adult DSH colony cats.</p> </sec> <sec id="jvim12493-sec-0004" sec-type="section"> <title>Methods</title> <p>Utilizing a randomized, 4‐way crossover design, cats received 0.88–1.26 mg/kg PO q12h fOT, ORP, famotidine, and placebo (lactose capsules). Intragastric pH monitoring was used to continuously record intragastric pH for 96 hours beginning on day 4 of treatment. Plasma omeprazole concentrations at steady state (day 7) were determined by high performance liquid chromatography (HPLC) with ultraviolet detection. Mean percentage time that intragastric pH was ≥3 and ≥4 were compared among groups using ANOVA with a posthoc Tukey‐Kramer test (α = 0.05).</p> </sec> <sec id="jvim12493-sec-0005" sec-type="section"> <title>Results</title> <p>The mean percentage time ± SD that intragastric pH was ≥3 was 68.4 ± 35.0% for fOT, 73.9 ± 23.2% for ORP, 42.8 ± 18.6% for famotidine, and 16.0 ± 14.2% for placebo. Mean ± SD plasma omeprazole concentrations were similar in cats receiving fOT compared to those receiving ORP and in a range associated with acid suppression reported in other studies.</p> </sec> <sec id="jvim12493-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>These results suggest that both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo. Fractionated enteric‐coated OT is an effective acid suppressant despite disruption of the enteric coating.</p> </sec> </abstract>