Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations. (30th September 2014)

• Record Type: Journal Article
• Authors: Kehrli, D.; Jandova, V.; Fey, K.; Jahn, P.; Gerber, V.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 1(2015:Jan./Feb.)
• Page Start: 320
• Page End: 326
• Publication Date: 2014-09-30
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12473
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12473-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12473-sec-0001" sec-type="section"> <title>Background</title> <p>Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses.</p> </sec> <sec id="jvim12473-sec-0002" sec-type="section"> <title>Hypotheses</title> <p>Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP <italic>BIEC2‐224511</italic>), previously shown to be associated with RAO.</p> </sec> <sec id="jvim12473-sec-0003" sec-type="section"> <title>Animals</title> <p>The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO‐affected Warmblood horses and 264 RAO‐unaffected controls. All horses were Warmbloods, 14 years or older.</p> </sec> <sec id="jvim12473-sec-0004" sec-type="section"> <title>Methods</title> <p>Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP <italic>BIEC2‐224511</italic> as well as management and environmental factors were investigated.</p> </sec> <sec id="jvim12473-sec-0005" sec-type="section"> <title>Results</title> <p>In P1, RAO‐affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (<italic>P</italic> = .004). In P2, the respective OR was 7.4 (<italic>P</italic> = .002) and IBH‐affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (<italic>P</italic> < .001). IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces.</p> </sec> <sec id="jvim12473-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>This is the first report of MHS in horses. Specifically, an increased risk for IBH should be expected in RAO‐affected horses.</p> </sec> </abstract>