Echocardiographic Evaluation of Myocardial Changes Observed After Closure of Patent Ductus Arteriosus in Dogs. (16th January 2015)

• Record Type: Journal Article
• Authors: Hamabe, L.; Kim, S.; Yoshiyuki, R.; Fukayama, T.; Nakata, T.M.; Fukushima, R.; Tanaka, R.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 1(2015:Jan./Feb.)
• Page Start: 126
• Page End: 131
• Publication Date: 2015-01-16
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12517
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12517-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12517-sec-0001" sec-type="section"> <title>Background</title> <p>Closure of PDA can be associated with echocardiographic changes including deterioration of LV systolic function. Although PDA is commonly encountered in dogs, few comprehensive reports of echocardiographic changes in dogs with PDA closure are available.</p> </sec> <sec id="jvim12517-sec-0002" sec-type="section"> <title>Objectives</title> <p>To evaluate the short‐term echocardiographic changes observed after PDA closure in dogs using strain analysis.</p> </sec> <sec id="jvim12517-sec-0003" sec-type="section"> <title>Animals</title> <p>Seventeen client‐owned dogs with left‐to‐right PDA.</p> </sec> <sec id="jvim12517-sec-0004" sec-type="section"> <title>Methods</title> <p>Echocardiographic evaluations, including standard echocardiography and two‐dimensional tissue tracking (2DTT), were performed before and within 3 days of PDA closure.</p> </sec> <sec id="jvim12517-sec-0005" sec-type="section"> <title>Results</title> <p>Preclosure examination showed LV and left atrial dilatation indicating volume overload as a result of PDA. Closure of PDA resulted in significant reduction of LVIDd (<.0001) and LA/Ao (0.01) without change in LVIDs, suggestive of decreased preload. Postclosure LV systolic dysfunction was observed with significant decreased in FS (<.0001) and strain values (<italic>P</italic> = .0039 for radial strains, <italic>P</italic> = .0005 for circumferential strains). Additionally, significant LV dyssynchrony (<italic>P</italic> = .0162) was observed after closure of PDA.</p> </sec> <sec id="jvim12517-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>Closure of PDA resulted in decreased preload as a result of alleviation of LV volume overload, which in turn caused transient deterioration of LV systolic function. Additionally, this study demonstrated that strain analysis is load dependent. Therefore, care should be taken when interpreting strain measurements as an indicator of LV systolic function.</p> </sec> </abstract>