Canine Pancreatic‐Specific Lipase Concentrations in Dogs with Heart Failure and Chronic Mitral Valvular Insufficiency. (14th January 2015)

• Record Type: Journal Article
• Authors: Han, D.; Choi, R.; Hyun, C.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 1(2015:Jan./Feb.)
• Page Start: 180
• Page End: 183
• Publication Date: 2015-01-14
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12521
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12521-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12521-sec-0001" sec-type="section"> <title>Background</title> <p>Chronic mitral valvular insufficiency (CMVI) in dogs is very common and might cause clinical signs of congestion and poor tissue perfusion.</p> </sec> <sec id="jvim12521-sec-0002" sec-type="section"> <title>Hypothesis</title> <p>Poor tissue perfusion from CMVI causes pancreatitis in dogs, as indicated by serum pancreatic lipase concentrations.</p> </sec> <sec id="jvim12521-sec-0003" sec-type="section"> <title>Animals</title> <p>Sixty‐two client‐owned dogs consisting of 40 dogs with different stages of heart failure from CMVI and 22 age‐matched healthy dogs, based on full cardiac exam and routine laboratory tests.</p> </sec> <sec id="jvim12521-sec-0004" sec-type="section"> <title>Methods</title> <p>Prospective, controlled, observational study. Serum canine pancreatic lipase immunoreactivity (cPLI) concentrations were determined by quantitative cPLI test in healthy and CMVI groups.</p> </sec> <sec id="jvim12521-sec-0005" sec-type="section"> <title>Results</title> <p>Serum cPLI concentrations were 54.0 μg/L (IQR: 38.0–78.8 μg/L) in control, 55.0 μg/L (IQR: 38.3–88.8 μg/L) in ISACHC I, 115.0 μg/L (IQR: 45.0–179.0 μg/L) in ISACHC II and 223.0 μg/L (IQR: 119.5–817.5 μg/L) in ISACHC III. Close correlation to serum cPLI concentration was found in the left atrial to aorta (LA/Ao) ratio (<italic>r</italic> = 0.597; <italic>P</italic> = .000) and the severity of heart failure (<italic>r</italic> = 0.530; <italic>P</italic> = .000).</p> </sec> <sec id="jvim12521-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>This study found CMVI is associated with pancreatic injury in congestive heart failure caused by CMVI. Therefore, periodic monitoring on cPLI could be useful in monitoring dogs in heart failure.</p> </sec> </abstract>