Apelin levels are higher in obese patients with endometrial cancer. Issue 2 (27th August 2014)

• Record Type: Journal Article
• Authors: Altinkaya, S. Ozlem; Nergiz, Sümeyra; Küçük, Mert; Yüksel, Hasan
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 41:Issue 2(2015:Feb.)
• Page Start: 294
• Page End: 300
• Publication Date: 2014-08-27
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12503
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jog12503-sec-0001" sec-type="section"> <title>Aim</title> <p>The aim of the present study was to evaluate serum concentrations of apelin, a newly discovered adipocytokine, in relation with tumor markers, metabolic profile and clinicopathologic features of patients with endometrial cancer.</p> </sec> <sec id="jog12503-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>A total of 46 women with endometrial cancer and 44 controls were eligible for the study. Clinicopathologic features and metabolic profile as well as apelin‐36 levels were evaluated in each subject.</p> </sec> <sec id="jog12503-sec-0003" sec-type="section"> <title>Results</title> <p>Women with endometrial cancer exhibited higher serum concentrations of apelin levels than controls (215.1 ± 59.8 pg/mL vs 177.3 ± 55.2 pg/mL, <italic>P</italic> = 0.002). Apelin levels were significantly correlated positively with body mass index, fasting insulin levels and homeostasis model assessment index (<italic>P</italic> < 0.05). When patients were further divided into obese (body mass index ≥ 30) and non‐obese women, apelin levels remained higher in women with endometrial cancer in the obese group (<italic>P</italic> = 0.006, 243.5 ± 49.2 pg/mL vs 200.5 ± 52.7 pg/mL, respectively); whereas these levels were similar in the non‐obese group (<italic>P</italic> = 0.879, 161.9 ± 37.5 pg/mL vs 159.6 ± 51.3, respectively). After adjustment for all possible confounding factors, age, apelin levels > 160 pg/mL, and diabetes mellitus were found to be associated with risk of endometrial cancer.</p> </sec> <sec id="jog12503-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The data of the present study suggest that higher levels of circulating apelin are associated with an increased risk of developing endometrial cancer in obese women.</p> </sec> </abstract>