Insulin sensitivity and brain reward activation in overweight Hispanic girls: a pilot study. Issue 1 (20th December 2013)

• Record Type: Journal Article
• Authors: Adam, T. C.; Tsao, S.; Page, K. A.; Hu, H.; Hasson, R. E.; Goran, M. I.
• Is Part Of: Pediatric obesity. Volume 10:Issue 1(2015:Feb.)
• Page Start: 30
• Page End: 36
• Publication Date: 2013-12-20
• Subjects: Obesity in children -- Periodicals; Obesity in adolescence -- Periodicals; Obesity -- Periodicals; Overweight children -- Periodicals; 618.92398
• DOI: 10.1111/j.2047-6310.2013.00210.x
• Languages: English
• ISSNs: 1747-7174

Abstract

<abstract abstract-type="main"> <title>Summary</title> <sec id="ijpo210-sec-0002" sec-type="section"> <title>Background</title> <p>Insulin resistance is a link between obesity and the associated disease risk. In addition to its role as an energy regulatory signal to the hypothalamus, insulin also modulates food reward.</p> </sec> <sec id="ijpo210-sec-0003" sec-type="section"> <title>Objective</title> <p>To examine the relationship of insulin sensitivity (SI) and fasting insulin with cerebral activation in response to food and non‐food cues in children.</p> </sec> <sec id="ijpo210-sec-0004" sec-type="section"> <title>Methods</title> <p>Twelve overweight Hispanic girls (age: 8–11) participated in two study visits, a frequently sampled intravenous glucose tolerance test and a functional neuroimaging session (GE HDxt 3.0Tesla) with visual stimulation tasks. Blocks of images (high calorie [HC], low calorie [LC] and non‐food [NF]) were presented in randomized order.</p> </sec> <sec id="ijpo210-sec-0005" sec-type="section"> <title>Results</title> <p>Comparing HC with NF, SI was inversely associated with activation in the anterior cingulate (r<sup>2</sup> = 0.65; <italic>P</italic> < 0.05), the insula (r<sup>2</sup> = 0.69; <italic>P</italic> < 0.05), the orbitofrontal cortex (r<sup>2</sup> = 0.74; <italic>P</italic> < 0.05), and the frontal and rolandic operculum (r<sup>2</sup> = 0.76; <italic>P</italic> < 0.001). Associations remained significant after adjustment for body mass index. Association of fasting insulin and cerebral activation disappeared after adjustment for waist circumference.</p> </sec> <sec id="ijpo210-sec-0006" sec-type="section"> <title>Conclusion</title> <p>In addition to weight loss, insulin sensitivity may pose an important target to regulate neural responses to food cues in the prevention of excessive weight gain.</p> </sec> </abstract>