Gleason drift in the NIHR ProtecT study. Issue 3 (7th January 2015)

• Record Type: Journal Article
• Authors: Oxley, Jon; Simpkin, Andrew; Goepel, John; Varma, Murali; Griffiths, David; Grigor, Ken; Mayer, Nick; Warren, Anne; Deshmukh, Nayneeta; Bhattarai, Selina; Dormer, John; Hounsome, Luke; Adamczyk, Lukasz A; Metcalfe, Christopher; Lane, J Athene; Davis, Michael; Donovan, Jenny L; Neal, David E; Hamdy, Freddy C; Robinson, Mary C; the ProtecT Study Group
• Is Part Of: Histopathology. Volume 66:Issue 3(2015)
• Page Start: 438
• Page End: 446
• Publication Date: 2015-01-07
• Subjects: Histology, Pathological -- Periodicals; 611.018
• DOI: 10.1111/his.12549
• Languages: English
• ISSNs: 0309-0167

Abstract

<abstract abstract-type="main" id="his12549-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="his12549-sec-0001" sec-type="section"> <title>Aims</title> <p>There is increasing evidence of Gleason score (GS) drift in prostatic core biopsies during the last two decades. The ProtecT study is a randomized controlled study and provides an excellent cohort to study the effect of time, prostate‐specific antigen (PSA) level, perineural invasion, tumour length and age on GS.</p> </sec> <sec id="his12549-sec-0002" sec-type="section"> <title>Methods and results</title> <p>The ProtecT study recruited men in the United Kingdom between 1999 and 2010. The Gleason scores were grouped into four categories ≤3 + 3, 3 + 4, 4 + 3 and ≥4 + 4 for analysis. Data from England between 2000 and 2012 were also available. A total of 3282 biopsies containing cancer were analysed. For each year of the ProtecT study, the odds of being diagnosed with a higher GS category increased by 4.9%. Higher GS was also associated with perineural invasion, increasing tumour length, age and PSA level. While biopsy GS from England was incomplete, it also showed a marked decrease in GS five and six tumours during the same period.</p> </sec> <sec id="his12549-sec-0003" sec-type="section"> <title>Conclusion</title> <p>There was GS drift from 3 + 3 to 3 + 4 with time in the ProtecT study, but there appeared to be no significant change in percentage of GS 4 + 3 or higher. This drift was less dramatic when compared to GS in the rest of England.</p> </sec> </abstract>