Genetic endowment of proinflammatory cytokine tumor necrosis factor‐α (–) 308 G > A polymorphism to Parthenium hysterophorus‐induced airborne contact dermatitis in an Indian cohort. (14th February 2014)

• Record Type: Journal Article
• Authors: Khatri, Rakesh; Akhtar, Nasim; Mukhopadhyay, Kasturi; Verma, Kaushal K.; Sethuraman, Gomathy; Sharma, Alpana
• Is Part Of: International journal of dermatology. Volume 54:Number 2(2015:Feb.)
• Page Start: 179
• Page End: 184
• Publication Date: 2014-02-14
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.12255
• Languages: English
• ISSNs: 0011-9059

Abstract

<abstract abstract-type="main" id="ijd12255-abs-0001"> <title>Abstract</title> <sec id="ijd12255-sec-0001" sec-type="section"> <title>Background</title> <p>Parthenium dermatitis is a common airborne allergic health problem that induces a cell‐mediated hypersensitivity immune response involving activated T lymphocytes, which culminates in injury to the skin. The disease is manifested as itchy erythematous papules and plaques and primarily affects the exposed areas and flexures. This study aimed to identify the role of tumor necrosis factor (TNF)‐α (−) 308 G>A polymorphism in the pathogenesis of parthenium dermatitis.</p> </sec> <sec id="ijd12255-sec-0002" sec-type="section"> <title>Materials and methods</title> <p>A total of 120 subjects, including 60 patients exclusively diagnosed for parthenium dermatitis and 60 healthy individuals, were included in the study. The genotyping of the TNF‐α (−) 308 G>A region was carried out by the amplification refractory mutational system.</p> </sec> <sec id="ijd12255-sec-0003" sec-type="section"> <title>Results</title> <p>In the present study, we demonstrated that polymorphism of the TNF‐α (–) 308 position (A and/or G) was not statistically significant, and there was no difference in the distribution of any alleles of this locus in cases and controls.</p> </sec> <sec id="ijd12255-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The present study suggests that there is a lack of association of potent proinflammatory cytokine TNF‐α (−) 308 G>A polymorphism in parthenium dermatitis in the Indian cohort. It interprets genetically endowed transcriptional capacity due to this particular single nucleotide polymorphism but does not support the prevalence of high serum levels of TNF‐α in parthenium‐induced skin allergic inflammation.</p> </sec> </abstract>