Impact of gestational diabetes mellitus and high maternal weight on the development of diabetes, hypertension and cardiovascular disease: a population‐level analysis. Issue 2 (12th December 2014)

• Record Type: Journal Article
• Authors: Kaul, P.; Savu, A.; Nerenberg, K. A.; Donovan, L. E.; Chik, C. L.; Ryan, E. A.; Johnson, J. A.
• Is Part Of: Diabetic medicine. Volume 32:Issue 2(2015:Feb.)
• Page Start: 164
• Page End: 173
• Publication Date: 2014-12-12
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12635
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12635-abs-0001"> <title>Abstract</title> <sec id="dme12635-sec-0001" sec-type="section"> <title>Aims</title> <p>To examine the association between gestational diabetes mellitus (GDM) and high maternal weight and the risk of development of chronic disease.</p> </sec> <sec id="dme12635-sec-0002" sec-type="section"> <title>Methods</title> <p>Women with singleton deliveries between April 1999 and March 2010 in Alberta, Canada, were categorized according to pre‐pregnancy weight (overweight ≥ 91 kg) and GDM status. Obstetric and neonatal outcomes, as well as the long‐term incidence of maternal diabetes, hypertension and cardiovascular disease were examined.</p> </sec> <sec id="dme12635-sec-0003" sec-type="section"> <title>Results</title> <p>Of 240 083 women, 213 765 (89%) had no GDM and were not overweight (reference group), 17 587 (7.3%) were overweight only, 7332 (3%) had GDM only and 1399 (0.6%) had GDM and were overweight. Significant differences in Caesarean section rates, induction rates and birthweight were observed across the four groups. During a median follow‐up of 5.3 years, diabetes incidence was 36% in the GDM and overweight, 18.8% in the GDM only, 4.8% in the overweight only and 1.1% in the reference group. With respect to hypertension and cardiovascular disease, the GDM and overweight group had the highest rates (26.8% and 3.1%, respectively) and the reference group had the lowest rates (5.8% and 1.0%, respectively). However, rates were similar in the GDM only (14.9% and 1.9%, respectively) and overweight only groups (14.9% and 1.5%, respectively).</p> </sec> <sec id="dme12635-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Not surprisingly, the presence of both high maternal weight and GDM compounds the risk of developing diabetes. However, the association between overweight alone and GDM alone and hypertension and cardiovascular disease appears similar suggesting a need for effective interventions to manage both these conditions to improve the health of these patients.</p> </sec> </abstract>