Genetic polymorphism related to exfoliative glaucoma is also associated with primary open‐angle glaucoma risk. (7th August 2014)

• Record Type: Journal Article
• Authors: Zanon‐Moreno, Vicente; Zanon‐Moreno, Laura; Ortega‐Azorin, Carolina; Asensio‐Marquez, Eva M; Garcia‐Medina, Jose Javier; Sanz, Pedro; Pinazo‐Duran, Maria D; Ordovás, Jose M; Corella, Dolores
• Is Part Of: Clinical & experimental ophthalmology. Volume 43:Number 1(2015)
• Page Start: 26
• Page End: 30
• Publication Date: 2014-08-07
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1111/ceo.12367
• Languages: English
• ISSNs: 1442-6404

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ceo12367-sec-0001" sec-type="section"> <title>Background</title> <p>To investigate the possible association of the rs2165241 polymorphism (C &gt; T) in <italic>LOXL1</italic> gene with the risk of primary open‐angle glaucoma in a Mediterranean population.</p> </sec> <sec id="ceo12367-sec-0002" sec-type="section"> <title>Methods</title> <p>The analysis of genetic polymorphisms was performed by standard TaqMan allelic discrimination technique, using a 7900HT Sequence Detection System (Applied Biosystems).</p> </sec> <sec id="ceo12367-sec-0003" sec-type="section"> <title>Results</title> <p>In a recessive genetic model, the T allele of the rs2165241 polymorphism was significantly associated with the risk of primary open‐angle glaucoma (TT vs. CC: odds ratios = 2.19, 95% confidence interval = [1.33–3.62]). After multivariate logistic regression model adjusted by age and weight, the magnitude of the association decreased but remained statistically significant (TT vs. CC: odds ratios = 2.07, 95% confidence interval = [1.20–3.57]).</p> </sec> <sec id="ceo12367-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This polymorphism seems to be associated with high risk for primary open‐angle glaucoma in a Mediterranean population.</p> </sec> </abstract>