Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse. (20th November 2014)

• Record Type: Journal Article
• Authors: Kim, Jueun; Park, Aesoon; Glatt, Stephen J.; Eckert, Tanya L.; Vanable, Peter A.; Scott‐Sheldon, Lori A. J.; Carey, Kate B.; Ewart, Craig K.; Carey, Michael P.
• Is Part Of: Addiction. Volume 110:Number 2(2015:Feb.)
• Page Start: 289
• Page End: 299
• Publication Date: 2014-11-20
• Subjects: Alcoholism -- Periodicals; Drug addiction -- Periodicals; 616.86
• DOI: 10.1111/add.12753
• Languages: English
• ISSNs: 0965-2140

Abstract

<abstract abstract-type="main" id="add12753-abs-0001"> <title>Abstract</title> <sec id="add12753-sec-0001" sec-type="section"> <title>Aims</title> <p id="add12753-para-0007">To investigate whether the effects of family conflict on adolescent drinking differed as a function of 5‐hydroxy tryptamine transporter‐linked polymorphic region (<italic>5‐HTTLPR</italic>) genotype cross‐sectionally and prospectively in two independent samples of adolescents.</p> </sec> <sec id="add12753-sec-0002" sec-type="section"> <title>Design</title> <p id="add12753-para-0008">Path analysis and multi‐group analysis of two prospective datasets were conducted.</p> </sec> <sec id="add12753-sec-0003" sec-type="section"> <title>Settings</title> <p id="add12753-para-0009">United States and United Kingdom.</p> </sec> <sec id="add12753-sec-0004" sec-type="section"> <title>Participants</title> <p id="add12753-para-0010">Sample 1 was 175 adolescents in the United States (mean age = 15 at times 1 and 2 with a 6‐month interval); Sample 2 was 4916 adolescents in the United Kingdon (mean age = 12 at time 1 and 15 at time 2).</p> </sec> <sec id="add12753-sec-0005" sec-type="section"> <title>Measurements</title> <p id="add12753-para-0011">In both samples, demographics, tri‐allelic <italic>5‐HTTLPR</italic> genotype and perceived family conflict were assessed at time 1. Alcohol use (frequency of drinking) and alcohol misuse (frequency of intoxication, frequency of drinking three or more drinks, maximum number of drinks) were assessed at times 1 and 2.</p> </sec> <sec id="add12753-sec-0006" sec-type="section"> <title>Findings</title> <p id="add12753-para-0012">A significant gene–environment interaction on alcohol misuse at time 1 was found in both sample 1 (β = 0.57, <italic>P</italic> = 0.001) and sample 2 (β = 0.19, <italic>P</italic> = 0.01), indicating that the <italic>5‐HTTLPR</italic> low‐activity allele carriers exposed to higher levels of family conflict were more likely to engage in alcohol misuse than non‐carriers. A significant gene–environment interaction effect on change in alcohol misuse over time was found only in sample 1 (β = 0.48, <italic>P</italic> = 0.04) but not in sample 2.</p> </sec> <sec id="add12753-sec-0007" sec-type="section"> <title>Conclusions</title> <p id="add12753-para-0013">Compared with non‐carriers, adolescents carrying the <italic>5‐HTTLPR</italic> low‐activity allele are more susceptible to the effects of family conflict on alcohol misuse.</p> </sec> </abstract>