Early radiation‐induced changes evaluated by intravoxel incoherent motion in the major salivary glands. Issue 4 (3rd April 2014)

• Record Type: Journal Article
• Authors: Marzi, Simona; Forina, Chiara; Marucci, Laura; Giovinazzo, Giuseppe; Giordano, Carolina; Piludu, Francesca; Landoni, Valeria; Spriano, Giuseppe; Vidiri, Antonello
• Is Part Of: Journal of magnetic resonance imaging. Volume 41:Issue 4(2015)
• Page Start: 974
• Page End: 982
• Publication Date: 2014-04-03
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24626
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24626-sec-0001" sec-type="section"> <title>Purpose</title> <p>To investigate the potential of intravoxel incoherent motion (IVIM) MRI for early evaluation of irradiated major salivary glands.</p> </sec> <sec id="jmri24626-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Thirty‐four patients with head‐neck cancer were included in a prospective study. All patients underwent three serial IVIM‐MRI: before, half‐way through, and at the end of radiotherapy (RT). Apparent diffusion coefficient (ADC), ADC<sub>low</sub> derived in the low <italic>b</italic>‐value range, perfusion fraction <italic>f</italic>, and pure diffusion coefficient D were estimated. Pretreatment values and early changes of diffusion parameters were correlated with parotid mean dose (D<sub>mean</sub>) and volume reduction after RT.</p> </sec> <sec id="jmri24626-sec-0003" sec-type="section"> <title>Results</title> <p>Changes in diffusion parameters over time were all significant (<italic>P</italic> < 0.001 for ADC, ADC<sub>low</sub>, and D, <italic>P</italic> = 0.003 for <italic>f</italic>). Variations of ADC, ADC<sub>low</sub>, and <italic>f</italic> were not correlated with D<sub>mean</sub> (<italic>P</italic> = 0.089, <italic>P</italic> = 0.252 and <italic>P</italic> = 0.884, respectively), whereas a significant relationship was found between changes in D and D<sub>mean</sub> (r = 0.197 with CI95% = 0.004–0.375, <italic>P</italic> = 0.046). Pretreatment <italic>f</italic> and D<sub>mean</sub> were the best independent predictors for the percentage shrinkage (<italic>P</italic> = 0.0003 and 0.0597 respectively; R<sup>2</sup> = 0.391).</p> </sec> <sec id="jmri24626-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Early changes of irradiated major salivary glands can be noninvasively evaluated by IVIM‐MRI. Perfusion‐related coefficients in conjunction with dosimetric information increase our capability to predict the change in parotid volume and hence, if further validated, guide treatment strategy in RT. <bold>J. Magn. Reson. Imaging 2015;41:974–982</bold>. © <bold>2014 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>