Are 5‐HT3 antagonists effective in obsessive–compulsive disorder? A systematic review of literature. (10th February 2015)

• Record Type: Journal Article
• Authors: Serata, Daniele; Kotzalidis, Georgios D.; Rapinesi, Chiara; Janiri, Delfina; Di Pietro, Simone; Callovini, Gemma; Piacentino, Daria; Gasperoni, Carlotta; Brugnoli, Roberto; Ferri, Vittoria Rachele; Girardi, Nicoletta; Tatarelli, Roberto; Ferracuti, Stefano; Angeletti, Gloria; Girardi, Paolo; Del Casale, Antonio
• Is Part Of: Human psychopharmacology. Volume 30:Number 2(2015)
• Page Start: 70
• Page End: 84
• Publication Date: 2015-02-10
• Subjects: Psychopharmacology -- Periodicals; Psychotropic drugs -- Periodicals; Psychopharmacology -- Periodicals; Psychotropic Drugs -- pharmacology -- Periodicals; 615.78
• DOI: 10.1002/hup.2461
• Languages: English
• ISSNs: 0885-6222

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hup2461-sec-0001" sec-type="section"> <title>Objective</title> <p>The purpose of this literature database search‐based review was to critically consider and evaluate the findings of literature focusing on efficacy and safety of 5‐HT<sub>3</sub> antagonists in the treatment of obsessive–compulsive disorder (OCD), so as to test whether preclinical data match clinical therapeutic trials.</p> </sec> <sec id="hup2461-sec-0002" sec-type="section"> <title>Design</title> <p>The PubMed database has been searched for papers on 5‐HT<sub>3</sub> antagonists and OCD in humans and for animal models of OCD and 5‐HT<sub>3</sub> receptors.</p> </sec> <sec id="hup2461-sec-0003" sec-type="section"> <title>Results</title> <p>Of the clinically tested 5‐HT<sub>3</sub> receptor antagonists, ondansetron has been used to treat OCD in five therapeutic studies, whereas granisetron only in one recent trial. Both showed some efficacy in open studies and superiority to placebo in double‐blind studies, along with fair safety. No animal OCD model directly implicated 5‐HT<sub>3</sub> receptors.</p> </sec> <sec id="hup2461-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Overall, results indicate some utility, but the available literature is too scanty to allow for valid conclusions to be drawn. The mismatch between animal models of obsessive–compulsive disorder and clinical data with 5‐HT<sub>3</sub> antagonists needs more clinical data to ensure that it is not an artefact. Copyright © 2015 John Wiley & Sons, Ltd.</p> </sec> </abstract>