Association of angiotensin‐converting enzyme gene polymorphism with schizophrenia and depressive symptom severity in a Chinese population. (19th February 2015)

• Record Type: Journal Article
• Authors: Hui, Li; Wu, Jing Qin; Ye, Min Jie; Zheng, Ke; He, Jin Cai; Zhang, Xuan; Liu, Jia Hong; Tian, Hai Jia; Gong, Ben Hong; Chen, Da Chun; Lv, Meng Han; Soares, Jair C.; Zhang, Xiang Yang
• Is Part Of: Human psychopharmacology. Volume 30:Number 2(2015)
• Page Start: 100
• Page End: 107
• Publication Date: 2015-02-19
• Subjects: Psychopharmacology -- Periodicals; Psychotropic drugs -- Periodicals; Psychopharmacology -- Periodicals; Psychotropic Drugs -- pharmacology -- Periodicals; 615.78
• DOI: 10.1002/hup.2460
• Languages: English
• ISSNs: 0885-6222

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hup2460-sec-0001" sec-type="section"> <title>Background</title> <p>Depressive symptoms are frequently observed in schizophrenia patients. Angiotensin‐converting enzyme (ACE), a key enzyme of renin‐angiotensin system, can catalyze the degradation of neuropeptides and modulate dopaminergic and serotonergic neurotransmission. Previous studies have revealed the association of the <italic>ACE</italic> gene insertion/deletion polymorphism with depressive disorder and its treatment response but not with the depressive symptoms in schizophrenia.</p> </sec> <sec id="hup2460-sec-0002" sec-type="section"> <title>Objective</title> <p>The aim of this study is to examine whether this polymorphism was associated with susceptibility to schizophrenia and with its psychopathological symptoms, especially depressive symptoms in a Han Chinese population.</p> </sec> <sec id="hup2460-sec-0003" sec-type="section"> <title>Methods</title> <p>This polymorphism was genotyped in 382 chronic patients and 538 healthy controls. Psychopathology was characterised using the positive and negative syndrome scale.</p> </sec> <sec id="hup2460-sec-0004" sec-type="section"> <title>Results</title> <p>The allelic and genotypic frequencies of this polymorphism significantly differed between patients and controls (both <italic>p</italic> < 0.001). A significant difference in the positive and negative syndrome scale depressive symptom score was observed among the three genotypes (<italic>p</italic> < 0.03), with higher score in patients with insertion/insertion (I/I) than with deletion/deletion (D/D) genotypes (<italic>p</italic> < 0.05). Furthermore, there was a significant linear correlation between the number of I alleles and the depressive symptom score (<italic>p</italic> < 0.05).</p> </sec> <sec id="hup2460-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The <italic>ACE</italic> gene insertion/deletion polymorphism may play a role in susceptibility to schizophrenia and also in its depressive symptom severity in a Han Chinese population. Copyright © 2015 John Wiley & Sons, Ltd.</p> </sec> </abstract>