Direct Trifluoromethylthiolation of Unactivated C(sp3)H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate1. (23rd February 2015)

• Record Type: Journal Article
• Authors: Wu, Hao; Xiao, Zhiwei; Wu, Junhui; Guo, Yong; Xiao, Ji‐Chang; Liu, Chao; Chen, Qing‐Yun
• Is Part Of: Angewandte Chemie. Volume 127:Number 13(2015)
• Page Start: 4142
• Page End: 4146
• Publication Date: 2015-02-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201411953
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp³)H bonds by AgSCF₃/K₂S₂O₈ under mild conditions is described. The reaction has a good functional‐group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K₂S₂O₈ plays key roles in both the activation of the C(sp³)H bond and the oxidation of AgSCF₃.</p> </abstract>