Do circulating cells transdifferentiate and replenish stem cell pools in the brain and periphery?. (24th February 2015)

• Record Type: Journal Article
• Authors: Mezey, Éva; Brownstein, Michael J.
• Is Part Of: BioEssays. Volume 37:Number 4(2015:Apr.)
• Page Start: 398
• Page End: 402
• Publication Date: 2015-02-24
• Subjects: Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.201400199
• Languages: English
• ISSNs: 0265-9247

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bies201400199-sec-0001" sec-type="section"> <p>For nearly two centuries, developmental biologists have known that body organs are derived from distinct germ layers. They have argued that adult stem cells formed in one of these, mesoderm for example, cannot give rise to cells that originate in another. We disagree. An exception to this "rule" has been described in crayfish recently. In this species, hemocytes appear to replenish neurogenic cells. This may happen in humans as well. In women who were given male bone marrow‐derived cells, Y chromosome positive cheek cells and brain neurons were detected. While repopulation of these tissues by bone marrow derived cells may not occur normally, and while it does not appear to be terribly efficient, the phenomenon should be studied in more detail. Perhaps cells in the marrow could be used to regenerate tissues elsewhere.</p> </sec> </abstract>