A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease1. Issue 3 (16th March 2015)
- Record Type:
- Journal Article
- Title:
- A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease1. Issue 3 (16th March 2015)
- Main Title:
- A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease1
- Authors:
- Beck, Michael W.
Oh, Shin Bi
Kerr, Richard A.
Lee, Hyuck Jin
Kim, So Hee
Kim, Sujeong
Jang, Milim
Ruotolo, Brandon T.
Lee, Joo-Yong
Lim, Mi Hee - Abstract:
- <abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj4121nxs" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />An <italic>in vivo</italic> chemical tool designed to target metal−Aβ complexes and modulate their activity was applied to the 5XFAD mouse model of Alzheimer's disease (AD) demonstrating the involvement of metal−Aβ in AD pathology.</p> </abstract>
- Is Part Of:
- Chemical science. Volume 6:Issue 3(2015:Mar.)
- Journal:
- Chemical science
- Issue:
- Volume 6:Issue 3(2015:Mar.)
- Issue Display:
- Volume 6, Issue 3 (2015)
- Year:
- 2015
- Volume:
- 6
- Issue:
- 3
- Issue Sort Value:
- 2015-0006-0003-0000
- Page Start:
- 1879
- Page End:
- 1886
- Publication Date:
- 2015-03-16
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/SC ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c4sc03239j ↗
- Languages:
- English
- ISSNs:
- 2041-6520
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3151.490000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 3466.xml