Direct biosynthetic cyclization of a distorted paracyclophane highlighted by double isotopic labelling of l-tyrosine1. Issue 12 (28th March 2015)

• Record Type: Journal Article
• Authors: Ear, Alexandre; Amand, Séverine; Blanchard, Florent; Blond, Alain; Dubost, Lionel; Buisson, Didier; Nay, Bastien
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 12(2015)
• Page Start: 3662
• Page End: 3666
• Publication Date: 2015-03-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00114e
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjbfzb4g7" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The biosynthesis of pyrrocidines was investigated using a double (¹⁸O, ¹³C) labelling of <sc>l</sc>-tyrosine. It shows that the phenolic ¹⁸O is incorporated during aryl ether bond formation.</p> </abstract>