Reversible PEGylation and Schiff-base linked imidazole modification of polylysine for high-performance gene delivery. Issue 8 (28th February 2015)

• Record Type: Journal Article
• Authors: Cai, Xiaojun; Li, Yongyong; Yue, Dong; Yi, Qiangying; Li, Shuo; Shi, Donglu; Gu, Zhongwu
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 8(2015)
• Page Start: 1507
• Page End: 1517
• Publication Date: 2015-02-28
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c4tb01724b
• Languages: English
• ISSNs: 2050-750X

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj412x6bc" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />In the designed polylysine based catiomer the reversible PEGylation was introduced for <italic>in vivo</italic> circulation and to augment the cellular internalization, while the Schiff-base linked imidazole to accelerate the endosomal escape and facilitate intracellular DNA unpacking and release.</p> </abstract>