Synthesis of 7-alkylidene-7, 12-dihydroindolo[3, 2-d]benzazepine-6-(5H)-ones (7-alkylidene-paullones) by N-cyclization–oxidative Heck cascade and characterization as sirtuin modulators1. Issue 9 (7th March 2015)

• Record Type: Journal Article
• Authors: Denis, J. G.; Franci, G.; Altucci, L.; Aurrecoechea, J. M.; de Lera, Á. R.; Álvarez, R.
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 9(2015)
• Page Start: 2800
• Page End: 2810
• Publication Date: 2015-03-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c4ob02493a
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj40zhtt9" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A palladium-induced cascade of N-cyclization and oxidative Heck reaction of <italic>o</italic>-alkynylanilines produced 7-alkylidene-indolobenzazepinones (paullones) that have sirtuin modulation activities.</p> </abstract>