Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway1. Issue 6 (14th February 2015)

• Record Type: Journal Article
• Authors: Zhang, Nannan; Liu, Shichang; Wang, Ning; Deng, Senyi; Song, Linjiang; Wu, Qinjie; Liu, Lei; Su, Weijun; Wei, Yuquan; Xie, Yongmei; Gong, Changyang
• Is Part Of: Nanoscale. Volume 7:Issue 6(2015)
• Page Start: 2609
• Page End: 2624
• Publication Date: 2015-02-14
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c4nr06300g
• Languages: English
• ISSNs: 2040-3364

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj410h2x1" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />For developing aqueous formulation and improving anti-tumor activity of JK184, we prepared JK184 encapsulated MPEG-PCL micelles which showed a stronger inhibition of Gli expression in Hh signaling in pancreatic carcinoma.</p> </abstract>