Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands1. Issue 7 (21st February 2015)

• Record Type: Journal Article
• Authors: Rodríguez-Bárzano, A.; Lord, R. M.; Basri, A. M.; Phillips, R. M.; Blacker, A. J.; McGowan, P. C.
• Is Part Of: Dalton transactions. Volume 44:Issue 7(2015)
• Page Start: 3265
• Page End: 3270
• Publication Date: 2015-02-21
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c4dt02748e
• Languages: English
• ISSNs: 1477-9226

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj40xw6w5" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A series of ruthenium complexes with <italic>η</italic>⁵-C₅(CH₃)₄R and diphosphine ligands have been synthesised and evaluated <italic>in vitro</italic> as anticancer agents. IC₅₀ values in the nanomolar range have been obtained against two types of cell lines.</p> </abstract>