Cofilin reduces the mechanical properties of actin filaments: approach with coarse-grained methods. Issue 12 (28th March 2015)

• Record Type: Journal Article
• Authors: Kim, Jae In; Kwon, Junpyo; Baek, Inchul; Park, Harold S.; Na, Sungsoo
• Is Part Of: Physical chemistry chemical physics. Volume 17:Issue 12(2015)
• Page Start: 8148
• Page End: 8158
• Publication Date: 2015-03-28
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/c4cp06100d
• Languages: English
• ISSNs: 1463-9076

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjbg58s7r" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />We applied a coarse-grained molecular dynamics simulation (CGMD) method and constructed elastic network model-based structures, actin and cofilactin filaments. Based on a normal mode analysis, the continuum beam theory was used to calculate the mechanical properties and the results showed good agreement with the established experimental data.</p> </abstract>