Asymmetric organocatalytic synthesis of quaternary α-hydroxy phosphonates: en route to α-aryl phosphaisoserines1. Issue 19 (7th March 2015)

• Record Type: Journal Article
• Authors: Serrano, Inmaculada; Monge, David; Álvarez, Eleuterio; Fernández, Rosario; Lassaletta, José M.
• Is Part Of: Chemical communications. Volume 51:Issue 19(2015)
• Page Start: 4077
• Page End: 4080
• Publication Date: 2015-03-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc10390d
• Languages: English
• ISSNs: 1359-7345

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj40v1hpc" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The dual activation of acyl phosphonates and formaldehyde <italic>tert</italic>-butyl hydrazone by a BINAM-derived bis-urea catalyst is the key to achieve high reactivities and enantioselectivities in the synthesis of densely functionalized quaternary α-hydroxy phosphonates.</p> </abstract>