<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj40vr8mc" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Nucleic acid based logic systems have been rationally designed and functionalized to better serve bioanalytical and biomedical applications.</p> </abstract>