Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells12. Issue 12 (11th February 2015)

• Record Type: Journal Article
• Authors: Saha, Abhijit; Mohapatra, Saswat; Kurkute, Prashant; Jana, Batakrishna; Mondal, Prasenjit; Bhunia, Debmalya; Ghosh, Subhajit; Ghosh, Surajit
• Is Part Of: Chemical communications. Volume 51:Issue 12(2015)
• Page Start: 2249
• Page End: 2252
• Publication Date: 2015-02-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc09390a
• Languages: English
• ISSNs: 1359-7345

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj9nqwgkt" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The Aβ peptide interacts with tubulin close to the vinblastine and GTP/GDP binding site, inhibits the tubulin polymerization rate, induces tubulin aggregation and causes the apoptotic death of A549, HeLa and MCF7 cells.</p> </abstract>