Determinants and Characteristics of Angle-Closure Disease in an Elderly Chinese Population. (April 2015)

• Record Type: Journal Article
• Authors: Ko, Yu-Chieh; Liu, Catherine J.; Hsu, Wen-Ming; Cheng, Ching-Yu; Kuang, Tung-Mei; Chou, Pesus
• Is Part Of: Ophthalmic epidemiology. Volume 22:Number 2(2015)
• Page Start: 109
• Page End: 115
• Publication Date: 2015-04
• Subjects: Blindness -- Prevention -- Periodicals; Eye -- Diseases -- Epidemiology -- Periodicals; Ophthalmology -- Periodicals; 614.5997
• DOI: 10.3109/09286586.2015.1012270
• Languages: English
• ISSNs: 0928-6586

Abstract

<abstract> <title>ABSTRACT</title> <p> <italic>Purpose</italic>: To determine factors associated with angle-closure disease, particularly in those with structural or functional damage to the eyes, in an elderly Chinese population.</p> <p> <italic>Methods</italic>: A total of 460 individuals aged over 72 years were recruited. The association of angle-closure diseases, including primary angle-closure suspect (PACS), primary angle-closure (PAC) and primary angle-closure glaucoma (PACG), with various systemic and ocular characteristics was evaluated using multivariate logistic regression analyses.</p> <p> <italic>Results</italic>: Of 374 phakic subjects, 199 (53.2%) had angle-closure disease, including 135 PACS, 46 PAC, and 18 PACG. The majority of those with untreated PACG (10/13, 76.9%) had presenting intraocular pressure (IOP) < 20 mmHg. Independent risk factors for angle-closure disease were lower Van Herick grading, shallower central anterior chamber depth (ACD), and higher post-mydriatic IOP (all <italic>p</italic> < 0.05). Central and peripheral ACD estimation correlated weakly, only 60.8% of angle-closure eyes had generalized narrowing of ACD as a Van Herick grading ≤2 and central ACD ≤ 2.83 mm. A criterion considering either central or peripheral ACD identified 91% of angle-closure eyes, including all PACG. A higher post-mydriatic IOP was associated with a diagnosis of PAC or PACG among angle-closure eyes (<italic>p</italic> = 0.002).</p> <p> <italic>Conclusion</italic>: Both central and peripheral ACD should be evaluated and shallowing of either one should be an indication for gonioscopic examination to maximize detection of angle-closure disease in elderly Chinese persons. PAC and PACG were associated with higher post-mydriatic IOP than PACS, although subjects with PACG frequently presented with normal IOP.</p> </abstract>