A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history. Issue 3 (23rd December 2014)

• Record Type: Journal Article
• Authors: Kato, H.; Nakayama, T.; Uruma, M.; Okuyama, Y.; Handa, M.; Tomiyama, Y.; Shimodaira, S.; Takamoto, S.
• Is Part Of: Vox sanguinis. Volume 108:Issue 3(2015)
• Page Start: 243
• Page End: 250
• Publication Date: 2014-12-23
• Subjects: Blood -- Periodicals; Blood -- Transfusion -- Periodicals; Immunohematology -- Periodicals; Immunopathology -- Periodicals; 615.39
• DOI: 10.1111/vox.12208
• Languages: English
• ISSNs: 0042-9007

Abstract

<abstract abstract-type="main" id="vox12208-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="vox12208-sec-0001" sec-type="section"> <title>Background and Objectives</title> <p>This study compares the frequency of adverse transfusion reactions (ATRs) after first transfusions with the frequency of ATRs for subsequent (non‐first) transfusions.</p> </sec> <sec id="vox12208-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Five hospitals agreed to systematically collect and share 2 years of data. This was a retrospective observational analysis of data including the number of transfusion episodes and ATRs for red blood cells (RBCs), fresh frozen plasma (FFP) and platelet concentrates (PCs) given to first‐time transfusion recipients and to those previously transfused.</p> </sec> <sec id="vox12208-sec-0003" sec-type="section"> <title>Results</title> <p>First transfusion ATRs to RBCs, FFP and PCs were 1·08%, 2·84% and 3·34%, respectively. These are higher than ATR incidences to RBCs (0·69%), FFP (1·91%) and PCs (2·75%) on subsequent transfusions. Specifically, first transfusion incidences of febrile non‐haemolytic transfusion reactions (FNHTRs) to RBCs (0·43%) and allergic reactions to FFP (2·51%) were higher than on subsequent transfusions (RBCs: 0·23%, FFP: 1·65%).</p> </sec> <sec id="vox12208-sec-0004" sec-type="section"> <title>Conclusion</title> <p>There are risks of ATRs on the first transfusion as well as transfusions of patients with transfusion history.</p> </sec> </abstract>