Anti‐inflammatory activity of lanoconazole, a topical antifungal agent. Issue 4 (10th February 2015)

• Record Type: Journal Article
• Authors: Uratsuji, Hideya; Nakamura, Aki; Yamada, Yoshihito; Hashimoto, Kei; Matsumoto, Tatsumi; Ikeda, Fumiaki; Ishii, Ritsuko
• Is Part Of: Mycoses. Volume 58:Issue 4(2015)
• Page Start: 197
• Page End: 202
• Publication Date: 2015-02-10
• Subjects: Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12297
• Languages: English
• ISSNs: 0933-7407

Abstract

<abstract abstract-type="main" id="myc12297-abs-0001"> <title>Summary</title> <p>Topical antifungal agents which have anti‐inflammatory effects have the potential to provide additional clinical benefits. Therefore, an anti‐inflammatory activity of lanoconazole (LCZ), a topical antifungal agent, was investigated against <italic>in vitro</italic> and <italic>in vivo</italic> models of inflammation. The release of interleukin‐8 (IL‐8) from human epidermal keratinocytes stimulated by the addition of 100 μg ml<sup>−1</sup> β‐glucan of <italic>Saccharomyces cerevisiae</italic> was significantly inhibited by LCZ at the concentration of 10<sup>−5</sup> mol l<sup>−1</sup>. The release of interferon‐γ and IL‐2 from human peripheral blood mononuclear cells stimulated by the addition of 30 and 100 μg ml<sup>−1</sup> phytohemagglutinin was significantly inhibited by LCZ at the concentrations of 10<sup>−7</sup> and 10<sup>−6</sup> mol l<sup>−1</sup>, respectively. The increase in the ear thickness induced by topical application of 0.01% 12‐<italic>O</italic>‐tetradecanoyl phorbol‐13‐acetate and 1% 2, 4, 6‐trinitrochlorobenzene (TNCB) after sensitisation with 3% TNCB were established as the mouse models of irritant and contact dermatitis, respectively. Application of 1% and 3% LCZ showed a significant anti‐inflammatory activity against both the irritant and contact dermatitis models. These findings suggest that LCZ possesses an anti‐inflammatory activity, which may be partially helpful in the treatment of dermatomycoses.</p> </abstract>