Ovarian steroid cell tumor, not otherwise specified: A clinicopathological and immunohistochemical experience of 12 cases. Issue 3 (27th October 2014)

• Record Type: Journal Article
• Authors: Haroon, Saroona; Idrees, Romana; Fatima, Saira; Memon, Aisha; Kayani, Naila
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 41:Issue 3(2015:Mar.)
• Page Start: 424
• Page End: 431
• Publication Date: 2014-10-27
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12537
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jog12537-sec-0001" sec-type="section"> <title>Aim</title> <p>Ovarian steroid cell tumors, not otherwise specified (SCT‐NOS) are very rare neoplasms. No large study has been performed in Pakistan to establish the clinicopathological spectrum and immunohistochemical behavior in our region. The purpose of our study was to determine the various clinicopathological and immunohistochemical features of ovarian SCT‐NOS along with follow‐up in our institution.</p> </sec> <sec id="jog12537-sec-0002" sec-type="section"> <title>Methods</title> <p>This was a retrospective observational study. The study was conducted in the Section of Histopathology, Aga Khan University Hospital, Karachi, Pakistan. All reported cases of ovarian SCT‐NOS occurring during January 1992 to August 2013 were retrieved. The slides were reviewed and patient demographics, and clinical and pathological features were noted with proforma software. SPSS version 19 was used for all analyses. Data is expressed as absolute values and percentages.</p> </sec> <sec id="jog12537-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 12 SCT‐NOS (2.3%) out of 528 ovarian sex cord stromal tumors were retrieved. The age range was 3–70 years, with mean of 40.75 years. The tumors ranged 2.5–13 cm in size, with a mean size of 6.1 cm. One patient had bilateral tumors. All of the tumors were positive for inhibin and calretinin. Four tumors were negative for Mic‐2 (CD99). In two patients, the tumor recurred. Only one patient who had worse pathological features received adjuvant chemotherapy.</p> </sec> <sec id="jog12537-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Steroid cell tumors are very rare ovarian tumors in the Pakistani population, mostly presenting in adulthood. Diverse histological differentials exist so special stains and immunohistochemical stains are needed to distinguish these from other tumors.</p> </sec> </abstract>