Efficacy of naftopidil for nocturia in male patients with lower urinary tract symptoms: Comparison of morning and evening dosing. (25th November 2014)

• Record Type: Journal Article
• Authors: Tanaka, Tomoaki; Kuratsukuri, Katsuyuki; Yoshimura, Rikio; Adachi, Takahisa; Yamaguchi, Tetsuo; Ohmachi, Tetsuji; Yamamoto, Shinji; Nakamura, Takahiro; Tamada, Satoshi; Nakatani, Tatsuya
• Is Part Of: International journal of urology. Volume 22:Number 3(2015)
• Page Start: 317
• Page End: 321
• Publication Date: 2014-11-25
• Subjects: Urology -- Periodicals; Genitourinary organs -- Periodicals; Urologic Diseases -- Periodicals; 616.6005
• DOI: 10.1111/iju.12669
• Languages: English
• ISSNs: 0919-8172

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="iju12669-sec-0001" sec-type="section"> <title>Objectives</title> <p>To examine the difference in improvement of lower urinary tract symptoms between morning and evening dosing of α<sub>1</sub>‐blocker naftopidil.</p> </sec> <sec id="iju12669-sec-0002" sec-type="section"> <title>Methods</title> <p>A total of 177 male patients with nocturia were included in the present study and randomized to morning or evening dosing of naftopidil. The International Prostate Symptom Score, quality of life index and nocturia quality of life index were compared between the two study groups at 12 weeks.</p> </sec> <sec id="iju12669-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 143 patients (morning group: <italic>n</italic> = 70, evening group: <italic>n</italic> = 73) were analyzed as a result of the dropout of 34 patients because of failure to give consent, adverse events and failure to attend. Nocturia, quality of life index and nocturia quality of life index at 12 weeks were significantly better in the evening group compared with the morning group. In a multivariate model, both the dosing time of naftopidil and the initial nocturia quality of life index were significantly associated with change in nocturia quality of life index.</p> </sec> <sec id="iju12669-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Evening dosing of naftopidil seems to be more effective in treating nocturia in male patients with lower urinary tract symptoms.</p> </sec> </abstract>