Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori‐associated Diseases: A Case‐control Study. Issue 2 (12th January 2015)

• Record Type: Journal Article
• Authors: Ichikawa, Hitomi; Sugimoto, Mitsushige; Uotani, Takahiro; Sahara, Shu; Yamade, Mihoko; Iwaizumi, Moriya; Yamada, Takanori; Osawa, Satoshi; Sugimoto, Ken; Miyajima, Hiroaki; Yamaoka, Yoshio; Furuta, Takahisa
• Is Part Of: Helicobacter. Volume 20:Issue 2(2015:Apr.)
• Page Start: 106
• Page End: 113
• Publication Date: 2015-01-12
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12183
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" id="hel12183-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hel12183-sec-0001" sec-type="section"> <title>Background</title> <p>Patients with duodenal ulcer have a reduced risk of developing gastric cancer compared to those without. Recently, the <italic>prostate stem cell antigen</italic> (<italic>PSCA</italic>) rs2294008 C>T polymorphism was found to be associated with different pathogenesis of duodenal ulcer and gastric cancer developments. However, whether <italic>PSCA</italic> rs2294008 C>T polymorphism is associated with severity of gastric mucosal atrophy is unclear. We examined the influence of the <italic>PSCA</italic> rs2294008 C>T polymorphism on susceptibility to <italic>H. pylori‐</italic>related diseases and the relationships between <italic>PSCA</italic> polymorphism and gastric mucosal atrophy.</p> </sec> <sec id="hel12183-sec-0002" sec-type="section"> <title>Methods</title> <p> <italic>PSCA</italic> rs2294008 C>T polymorphism was assessed in <italic>H. pylori</italic>‐positive Japanese patients (n = 488) with noncardia gastric cancer (n = 193), gastric ulcer (n = 84), duodenal ulcer (n = 61), and atrophic gastritis (n = 150), as well as in <italic>H. pylori</italic>‐negatives (n = 266).</p> </sec> <sec id="hel12183-sec-0003" sec-type="section"> <title>Results</title> <p>Frequency of <italic>PSCA</italic> rs2294008 C/C genotype in duodenal ulcer was 36.1%, which was significantly higher than those with gastric cancer (12.4%), gastric ulcer (19.0%), gastritis (10.7%), and <italic>H. pylori</italic>‐negatives (19.5%) (<italic>p</italic> < .001). Compared with duodenal ulcer, having the T allele significantly increased the risk of gastric cancer (OR: 3.97, 95% CI: 2.02–7.80; <italic>p</italic> < .001), gastric ulcer (2.40, 1.13–5.10; <italic>p</italic> = .023), and gastritis (4.72, 2.26–9.86; <italic>p</italic> < .001). Mean pepsinogen (PG) I/PG II ratio in T allele carriers (2.17 ± 0.75) was significantly lower than that in C/C genotype (3.39 ± 1.27, <italic>p </italic>< .001).</p> </sec> <sec id="hel12183-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The <italic>PSCA</italic> rs2294008 C>T polymorphism is associated with differing susceptibilities to <italic>H. pylori</italic>‐associated diseases. The <italic>PSCA</italic> rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in <italic>PSCA</italic> rs2294008 T allele carriers, but not duodenal ulcer.</p> </sec> </abstract>