One‐year protocol biopsies from ABO‐incompatible renal allografts compared with a matched cohort of ABO‐compatible allografts. (6th February 2015)

• Record Type: Journal Article
• Authors: Dörje, Christina; Mjøen, Geir; Strøm, Erik H.; Holdaas, Hallvard; Jenssen, Trond; Øyen, Ole; Akalin Akkök, Çigdem; Cvancarova, Milada; Midtvedt, Karsten; Reisæter, Anna Varberg
• Is Part Of: Clinical transplantation. Volume 29:Number 3(2015)
• Page Start: 268
• Page End: 276
• Publication Date: 2015-02-06
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.12515
• Languages: English
• ISSNs: 0902-0063

Abstract

<abstract abstract-type="main" id="ctr12515-abs-0001"> <title>Abstract</title> <sec id="ctr12515-sec-0001" sec-type="section"> <title>Introduction</title> <p>Early acute antibody‐mediated rejection (ABMR) occurs more frequently in ABO‐incompatible (ABOi) than in ABO‐compatible (ABOc) kidney transplantation. This could lead to increased inflammation/scarring in the ABOi grafts. Protocol biopsy data in ABOi kidney recipients are scarce.</p> </sec> <sec id="ctr12515-sec-0002" sec-type="section"> <title>Methods</title> <p>A single‐center retrospective matched cohort study was conducted. Eighty adult living donor (LD) renal transplant recipients without HLA donor‐specific antibodies (DSA) transplanted between 2009 and 2012 were included; 20 ABOi and 60 ABOc controls matched for donor age and transplantation year. Protocol biopsies at one yr were scored according to the Banff classification. Three sums of scores were constructed: tubulointerstitial inflammation (<italic>t</italic> + <italic>i</italic> = 0 vs. >0), microvascular inflammation (<italic>g</italic> + ptc = 0 vs. >0), scarring/hyalinosis (ci + ct + cv + ah ≤ 1 vs. >1. Scores and presence of subclinical rejection (SCR) at one yr were compared.</p> </sec> <sec id="ctr12515-sec-0003" sec-type="section"> <title>Results</title> <p>Protocol biopsy findings at one yr in the ABOi vs. ABOc matched control group were not statistically different: (<italic>t</italic> + <italic>i</italic>) > 0, 30% vs. 20%; (<italic>g</italic> + ptc) > 0, 5% vs. 8%; (ci + ct + cv + ah) > 1, 85% vs. 60%, respectively. No transplant glomerulopathy occurred. SCR rate at one yr was 30% vs. 18%, subclinical ABMR 5% vs. 7% (all with <italic>de novo </italic>HLA DSA).</p> </sec> <sec id="ctr12515-sec-0004" sec-type="section"> <title>Conclusion</title> <p>One‐year protocol biopsies of ABOi and ABOc LD recipients do not differ in chronic changes, inflammation, or SCRs.</p> </sec> </abstract>