Ovarian preservation in young women with endometrial cancer of endometrioid histology. (1st March 2015)

• Record Type: Journal Article
• Authors: Kinjyo, Yoshino; Kudaka, Wataru; Ooyama, Takuma; Inamine, Morihiko; Nagai, Yutaka; Aoki, Yoichi
• Is Part Of: Acta obstetricia et gynecologica Scandinavica. Volume 94:Number 4(2015)
• Page Start: 430
• Page End: 434
• Publication Date: 2015-03-01
• Subjects: Gynecology -- Periodicals; Pregnancy -- Periodicals; Obstetrics -- Periodicals; 618.05
• DOI: 10.1111/aogs.12588
• Languages: English
• ISSNs: 0001-6349

Abstract

<abstract abstract-type="main" id="aogs12588-abs-0001"> <title>Abstract</title> <sec id="aogs12588-sec-0001" sec-type="section"> <title>Objective</title> <p>To clarify the frequency and risk factors of ovarian metastasis in women with endometrial cancer of endometrioid histology.</p> </sec> <sec id="aogs12588-sec-0002" sec-type="section"> <title>Design</title> <p>Retrospective observational study.</p> </sec> <sec id="aogs12588-sec-0003" sec-type="section"> <title>Setting</title> <p>University of the Ryukyus Japan 1990–2011.</p> </sec> <sec id="aogs12588-sec-0004" sec-type="section"> <title>Population</title> <p>Eighty‐eight women ≤45 years of age with endometrial cancer of only endometrioid histology.</p> </sec> <sec id="aogs12588-sec-0005" sec-type="section"> <title>Methods</title> <p>Clinicopathological factors from the medical records were used. Fisher's exact test and logistic regression analysis were used to analyze predictive factors for ovarian metastasis.</p> </sec> <sec id="aogs12588-sec-0006" sec-type="section"> <title>Main outcome measures</title> <p>Risk factors of ovarian malignancy.</p> </sec> <sec id="aogs12588-sec-0007" sec-type="section"> <title>Results</title> <p>All women underwent total abdominal hysterectomy, bilateral salpingo‐oophorectomy and lymph node dissection. The median age was 39 years, and FIGO stage distributions were: stage I, 63 (71.6%) women; stage II, 14 (15.9%) women; and stage III, 11 (12.5%) women. Pathologically, ovarian metastasis was observed in four (4.5%) women. Only lymph node metastasis was a significant predictive factor for ovarian metastasis (<italic>p</italic> = 0.0038), and deep myometrial invasion was the only significant factor (<italic>p</italic> = 0.0085) for the prediction of lymph node metastasis. No ovarian malignancy was found in 72 women with invasion ≤50% myometrial depth and no enlargement of the ovaries. We observed ovarian metastasis in two (14.3%) of 14 women with deep myometrial invasion without ovarian tumor.</p> </sec> <sec id="aogs12588-sec-0008" sec-type="section"> <title>Conclusion</title> <p>Ovarian preservation surgery might be considered in endometrial cancer of endometrioid histology with ≤50% myometrial depth invasion with no ovarian mass after taking into account family history.</p> </sec> </abstract>