Chorea due to diabetic hyperglycemia and uremia: Distinct clinical and imaging features. Issue 3 (4th February 2015)

• Record Type: Journal Article
• Authors: Kim, Young Jin; Kim, Sang Joon; Kim, Juyeon; Kim, Mi‐Jung; Kim, Ki‐Ju; Yoon, Hyukjun; Kim, Sung Reul; Chung, Sun Ju
• Is Part Of: Movement disorders. Volume 30:Issue 3(2015)
• Page Start: 419
• Page End: 422
• Publication Date: 2015-02-04
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26148
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>This study was undertaken to describe the clinical and imaging characteristics of patients with chorea associated with nonketotic hyperglycemia (C‐NKH) in comparison with patients with chorea associated with uremia (C‐URE). We retrospectively analyzed the clinical data of consecutive 10 C‐NKH and five C‐URE patients who were treated between January 1, 2001 and January 31, 2013. Women were more frequently affected by C‐NKH (70% vs. 30%) and C‐URE (80% vs. 20%) compared with men. The C‐NKH patients demonstrated T1–hyperintense and inhomogeneous lesions in the basal ganglia, whereas C‐URE patients demonstrated T2‐hyperintense and homogeneous lesions in the basal ganglia. The mean time for chorea resolution after treatment was significantly shorter in C‐NKH patients than in C‐URE patients (4.4 ± 2.6 d vs. 73.8 ± 14.2 d, respectively; <italic>P</italic> = 0.005). The clinical and imaging features are remarkably different between C‐NKH and C‐URE patients, suggesting distinct pathogenic mechanisms. © 2015 International Parkinson and Movement Disorder Society</p> </abstract>