Concurrent Nucleotide Substitution Mutations in the Human Genome Are Characterized by a Significantly Decreased Transition/Transversion Ratio. Issue 3 (March 2015) - Zhu, Wenjuan
Abstract Employing disease‐causing mutations as a model system, we have previously reported a "separation distance" signature and a GC/GC>AA/TT mutational signature of concurrently generated multiple‐nucleotide substitution (MNS) mutations in the Journal. Here, employing again disease‐causing mutations as a model system, we report a further mutational signature of concurrently generated MNS mutations: they exhibit a >twofold lower transitions/transversions ratio than independently generated single nucleotide substitution mutations.