Dynamics of pulmonary venous flow in fetuses with intrauterine growth restriction. (29th December 2014)

• Record Type: Journal Article
• Authors: Bravo‐Valenzuela, Nathalie J. M.; Zielinsky, Paulo; Huhta, James C.; Acacio, Gregório L.; Nicoloso, Luiz H.; Piccoli, Antonio; Busato, Stefano; Klein, Caroline
• Is Part Of: Prenatal diagnosis. Volume 35:Number 3(2015:Mar.)
• Page Start: 249
• Page End: 253
• Publication Date: 2014-12-29
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4529
• Languages: English
• ISSNs: 0197-3851

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="pd4529-sec-0001" sec-type="section"> <title>Objective</title> <p>To test the hypothesis that the pulmonary vein pulsatility index (PVPI) is higher in fetuses with growth restriction (IUGR) than in normal fetuses.</p> </sec> <sec id="pd4529-sec-0002" sec-type="section"> <title>Methods</title> <p>Twenty‐two fetuses with IUGR and twenty‐one (21) fetuses with appropriate growth for gestational age from healthy mothers were studied. PVPI was calculated by Doppler echocardiography [maximal velocity (systolic or diastolic peak) − pre‐systolic peak / mean velocity]. Obstetric ultrasound was used to assess fetal biometry and Doppler to assess the uterine, umbilical and middle cerebral arteries PI. Statistical analysis used <italic>t</italic> test and Pearson's correlation.</p> </sec> <sec id="pd4529-sec-0003" sec-type="section"> <title>Results</title> <p>Mean gestational age was 31.5 +/− 2.1 weeks in the control group and 31.4 +/− 3.1 weeks in IUGR (<italic>P</italic> = 0.91). The PI of uterine and umbilical arteries were higher in IUGR than in controls (<italic>P</italic> < 0.001). Mean PVPI in IUGR fetuses was 1.31 +/− 0.41, and in controls it was 0.83 +/− 0.11 (<italic>P</italic> < 0.001).</p> </sec> <sec id="pd4529-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The pulsatility index of pulmonary venous flow in fetuses with growth restriction is higher than in normal fetuses, probably as a result of left atrial dynamics alteration secondary or not to fetal left ventricular diastolic dysfunction. © 2014 John Wiley & Sons, Ltd.</p> </sec> </abstract>