Uterine and umbilical artery Doppler at 28 weeks for predicting adverse pregnancy outcomes in women with abnormal uterine artery Doppler findings in the early second trimester. (5th January 2015)

• Record Type: Journal Article
• Authors: Ventura, Walter; De Paco Matallana, Catalina; Prieto‐Sanchez, Maria Teresa; Macizo, María Isabel; Pertegal, Miriam; Nieto, Aníbal; Delgado, Juan L.
• Is Part Of: Prenatal diagnosis. Volume 35:Number 3(2015:Mar.)
• Page Start: 294
• Page End: 298
• Publication Date: 2015-01-05
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4542
• Languages: English
• ISSNs: 0197-3851

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="pd4542-sec-0001" sec-type="section"> <title>Objective</title> <p>The objective of this study was to determine the contribution of uterine (UtA) and umbilical arteries (UA) Doppler examination at 28 weeks to predict adverse pregnancy outcomes in women who had increased resistance in UtA in the early second trimester.</p> </sec> <sec id="pd4542-sec-0002" sec-type="section"> <title>Methods</title> <p>Women with UtA mean pulsatility index (PI) above the 95th centile at 19–22 weeks of gestation were offered a growth scan including Doppler examination of UtA and UA at 28 weeks. Adverse pregnancy outcomes included small for gestational age (SGA), defined as birth weight below the tenth centile, preeclampsia (PE) and early‐onset PE (PE before 34 weeks).</p> </sec> <sec id="pd4542-sec-0003" sec-type="section"> <title>Results</title> <p>We studied 266 pregnant women with elevated PI in the UtAs in the second trimester and ultrasound reassessment at 28 weeks. UtA PI >95th centile at 28 weeks was associated with subsequent PE [odds ratio (OR): 10.0, 95% CI: 2.3–43.5], early‐onset PE (OR: 57.7, 95% CI: 3.8–87.6) and SGA less than the tenth centile (OR: 5.5, 2.2–13.9). UA PI >95th centile at 28 weeks was not significantly associated with any adverse outcome.</p> </sec> <sec id="pd4542-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In women with abnormal UtA Doppler in the early second trimester scan, persistence of elevated UtA PI, but not abnormal UA PI, is associated with adverse pregnancy outcomes including PE, early‐onset PE and SGA. © 2014 John Wiley & Sons, Ltd.</p> </sec> </abstract>