<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The first asymmetric hydrogenation of 2‐substituted and 2, 3‐substituted 5, 6‐dihydropyrazines catalyzed by a chiral cationic Ru‐diamine complex affords chiral piperazine derivatives with good enantioselectivity and good yield.</p> </abstract>