Clickable 5′‐γ‐Ferrocenyl Adenosine Triphosphate Bioconjugates in Kinase‐Catalyzed Phosphorylations. Issue 13 (9th February 2015)

• Record Type: Journal Article
• Authors: Wang, Nan; She, Zhe; Lin, Yen‐Chun; Martić, Sanela; Mann, David J.; Kraatz, Heinz‐Bernhard
• Is Part Of: Chemistry. Volume 21:Issue 13(2015)
• Page Start: 4988
• Page End: 4999
• Publication Date: 2015-02-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201405510
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Clickable co‐substrate</bold>: A tri‐functional 5′‐γ‐ferrocenyl adenosine triphosphate (Fc‐ATP) derivative containing a clickable site was synthesized (see figure). This compound is an effective co‐substrate in kinase‐catalyzed phosphorylation reactions, which can be detected by both electrochemical and immunoassay detection methods. The clickable reaction site makes direct modification possible, which greatly expands its application.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjb7mv45w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>