Absolute Asymmetric Synthesis: Protected Substrate Oxidation. Issue 13 (12th February 2015)

• Record Type: Journal Article
• Authors: Olsson, Susanne; Björemark, Per Martin; Kokoli, Theonitsa; Sundberg, Jonas; Lennartson, Anders; McKenzie, Christine J.; Håkansson, Mikael
• Is Part Of: Chemistry. Volume 21:Issue 13(2015)
• Page Start: 5211
• Page End: 5219
• Publication Date: 2015-02-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201406354
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Three new conglomerates incorporating bidentate sulfide ligands coordinated by Ru^II centers have been prepared. Total spontaneous resolution by slow crystallization gives highly enantioenriched crystal batches, which are used in enantioselective oxidation of the sulfide ligands to give chiral sulfoxide complexes with &gt;98 % <italic>ee</italic>. All relevant stereoisomers have been characterized by single‐crystal X‐ray diffraction, CD spectroscopy, and chiral HPLC. If the ligand range can be extended to monodentate sulfides, a large‐scale and recyclable process for enantioselective oxidation of sulfides can be designed.</p> </abstract>