Metabolic engineering of clostridia for the production of chemicals. (30th December 2014)

• Record Type: Journal Article
• Authors: Cho, Changhee; Jang, Yu‐Sin; Moon, Hyeon Gi; Lee, Joungmin; Lee, Sang Yup
• Is Part Of: Biofuels, bioproducts and biorefining. Volume 9:Number 2(2015:Mar./Apr.)
• Page Start: 211
• Page End: 225
• Publication Date: 2014-12-30
• Subjects: Biomass energy -- Periodicals; Biological products -- Periodicals; Fuel -- Refining -- Periodicals; 662.8805
• DOI: 10.1002/bbb.1531
• Languages: English
• ISSNs: 1932-104X

Abstract

<abstract abstract-type="main" id="bbb1531-abs-0001"> <title>Abstract</title> <p id="bbb1531-para-0006">There have recently been significant advances in bio‐based production of chemicals from renewable resources. Microorganisms belonging to the genus <italic>Clostridium</italic> have been considered as one of the promising hosts for the production of desired chemicals of wide industrial use. <italic>Clostridium</italic> strains have capability to utilize diverse carbon sources, including C5 and C6 substrates, which thus allows production of chemicals from inexpensive and abundant biomass such as corn stover, straw, and woody waste. In addition, <italic>Clostridium</italic> strains naturally produce various chemicals, such as acetic acid, butyric acid, ethanol, isopropanol, butanol, 1, 3‐propanediol, 2, 3‐butanediol, and acetone. Recently, several important strategies for the metabolic engineering of <italic>Clostridium</italic> have been developed not only for the enhanced production of these natural products and but also for the production of non‐natural isobutanol production. Here, we review the strategies employed for the development of metabolically engineered <italic>Clostridium</italic> strains for the production of such chemicals and provide future perspectives.</p> </abstract>