Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Issue 2 (28th January 2015)

• Record Type: Journal Article
• Authors: MacRae, Sheila L.; Zhang, Quanwei; Lemetre, Christophe; Seim, Inge; Calder, Robert B.; Hoeijmakers, Jan; Suh, Yousin; Gladyshev, Vadim N.; Seluanov, Andrei; Gorbunova, Vera; Vijg, Jan; Zhang, Zhengdong D.
• Is Part Of: Aging cell. Volume 14:Issue 2(2015:Apr.)
• Page Start: 288
• Page End: 291
• Publication Date: 2015-01-28
• Subjects: Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.12314
• Languages: English
• ISSNs: 1474-9718

Abstract

<abstract abstract-type="main" id="acel12314-abs-0001"> <title>Summary</title> <p>Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM‐associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of <italic>CEBPG</italic>, a regulator of DNA repair, and <italic>TINF2</italic>, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long‐lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.</p> </abstract>