Biodegradable Micelles Capable of Mannose‐Mediated Targeted Drug Delivery to Cancer Cells. Issue 5 (23rd January 2015)

• Record Type: Journal Article
• Authors: Yin, Lichen; Chen, Yongbing; Zhang, Zhonghai; Yin, Qian; Zheng, Nan; Cheng, Jianjun
• Is Part Of: Macromolecular rapid communications. Volume 36:Issue 5(2015:Mar.)
• Page Start: 483
• Page End: 489
• Publication Date: 2015-01-23
• Subjects: Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201400650
• Languages: English
• ISSNs: 1022-1336

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac‐OCA)‐<italic>b</italic>‐(poly(Tyr(alkynyl)‐OCA)‐<italic>g</italic>‐mannose) (PLA‐<italic>b</italic>‐(PTA‐<italic>g</italic>‐mannose), that is synthesized via controlled ring‐opening polymerization of <italic>O</italic>‐carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj43381ps" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>