Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment. (17th December 2014)

• Record Type: Journal Article
• Authors: Pedron, Sara; Becka, Eftalda; Harley, Brendan A.
• Is Part Of: Advanced materials. Volume 27:Number 9(2015)
• Page Start: 1567
• Page End: 1572
• Publication Date: 2014-12-17
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201404896
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201404896-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>There is an acute need for biomaterial tools</bold> that recreate the heterogeneous brain‐tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor‐inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj42zdhvw" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>