Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells. (15th January 2015)

• Record Type: Journal Article
• Authors: Reátegui, Eduardo; Aceto, Nicola; Lim, Eugene J.; Sullivan, James P.; Jensen, Anne E.; Zeinali, Mahnaz; Martel, Joseph M.; Aranyosi, Alexander J.; Li, Wei; Castleberry, Steven; Bardia, Aditya; Sequist, Lecia V.; Haber, Daniel A.; Maheswaran, Shyamala; Hammond, Paula T.; Toner, Mehmet; Stott, Shannon L.
• Is Part Of: Advanced materials. Volume 27:Number 9(2015)
• Page Start: 1593
• Page End: 1599
• Publication Date: 2015-01-15
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201404677
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201404677-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A layer‐by‐layer gelatin nanocoating</bold> is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj42zdnnq" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>